A: In reviewing the original answer, this may have been confusing. The statement means that you should use the cost associated with the processing, preserving, and transporting of the tissue when you set your charge. Medicare pays this service based on reasonable cost basis, which means that it applies the cost-to-charge ratio to the line item in order to determine what your cost for the service was. The standard markup can be used, but you want to be sure you use only the cost related to the corneal tissue and nothing else on that line item. This will ensure not only that you receive appropriate reimbursement, but that you also report the correct cost to the Medicare program.